A French scientist first discovered creatine in 1832, but it was not until 1923 that scientists discovered that over 95% of creatine is stored in muscle tissue. The first published report of creatine having bodybuilding effects was The Journal of Biological Chemistry in, get this, 1926! Although we’ve known about creatine for quite some time, the first real use of it to enhance performance was the 1992 Olympic games in Barcelona, Spain.

So, what is creatine? Our bodies naturally make the compound, which is used to supply energy to our muscles. It is produced in the liver, pancreas, and kidneys, and is transported to the body’s muscles through the bloodstream. Once it reaches the muscles, it is converted into phosphocreatine (creatine phosphate). This high-powered metabolite is used to regenerate the muscles’ ultimate energy source, ATP (adenosine triphosphate).

Creatine is 100% natural and occurs naturally in many foods; therefore, it can never be banned from any sports or international competitions (unless they banned eating meat)Many foods especially herring, salmon, tuna, and beef contain some creatine. However, the very best source of creatine by far is creatine monohydrate because it contains more creatine per weight of material than any other source.

Creatine is bodybuilding’s ultimate supplement, and for good reason. For one thing, creatine can significantly increase lean muscle mass in just two weeks. It is also responsible for improving performance in high-intensity exercise, increasing energy levels, and speeding up recovery rates. It’s no wonder athletes who use it have such of an edge over those who do not. Creatine’s ability to enhance energy reserves in muscles comes from its muscle protein synthesizing action, while minimizing protein breakdown. This occurs because creatine has the awesome effect of super-hydrating muscle cells with water. It enhances muscles’ growth too-making muscle fibers bigger and stronger.

Many studies have been done on creatine to figure out why and how it works so well. There have been over twenty double blind studies conducted on creatine in the past five years. They proved that creatine increased energy levels, resulting in increased strength, endurance levels, and recovery rates. Another unexpected benefit attributed to creatine was discovered as well: creatine accelerates fat loss, while building lean body mass!

How much should be taken? Are there any side effects?

Excellent results have been observed in taking creatine monohydrate in two different ways. The first way is called loading. This method works very well for anyone who has never taken creatine before. Just as the name implies, it involves loading up or saturating your muscles with creatine. During the first four days to a week, take 20 to 30 grams per day. Mix it with non-acidic juice or water. Grape juice works well. After this loading period, take a regular intake of between five to fifteen grams per day to keep your muscles saturated (no need to over do it). The other method is a more gradual approach to supplementing with creatine monohydrate. Over the course of an extended period, one basically skips the loading phase and just supplements with five to fifteen grams per day, everyday. The best results have been noticed when creatine is combined with a high carbohydrate base, such as dextrose (glucose) and taken about one-half hour before training.

The best part about creatine-no adverse effects have been reported in any studies. NONE! Creatine is totally safe and effective. Creatine has never been shown harmfully toxic. Nevertheless, just like with anything, it is not recommended to over-supplement once your muscles are saturated with creatine-there is no reason to. This means, stick to the recommended dosages, drink plenty of water and be prepared to experience fantastic muscle, strength, energy, and endurance gains!

Plain Old Creatine by Jason's Fitness

Creatine High Points:

•Increase Muscle Hardness • Increase Protein Synthesis • Increases Muscle Strength • Enhances Recovery • Increases Muscle Cell Hydration • Enhances Immune System • Enhances Glycogen Stores

Creatine For Brain Power

Title: Oral creatine monohydrate supplementation improves brain performance: a double-blind, placebo-controlled, cross-over trial

Author(s): Rae and others

Source: Proceedings: Biological Sciences

DOI: 10.1098/rspb.2003.2492

Publisher: The Royal Society

Creatine power

Athletes and fitness fanatics have known that creatine supplementation can increase sports performance and the compound - a close relative of the amino acids - has also been trialed successfully in the treatment of neurological, neuromuscular and atherosclerotic disease. “We know that creatine plays a pivotal role in maintaining energy levels in the brain,” says Dr. Rae. “So it was a reasonable hypothesis that supplementing a diet with creatine could assist brain function.”

The experiment tested this hypothesis by giving the one group of subjects a creatine supplement and a second group a placebo for six weeks, followed by a six week period with no intake and a final six week period when the control and placebo group were swapped. Intelligence and memory were tested at four points: the start of the trial; the end of the first six week period; and the start and endpoint of the final six week period.

Testing tasks

The effect on working memory was tested using a backward digit span test in which the subject has to repeat in reverse order progressively longer verbal random number sequences. Intelligence was tested using Ravens Advanced Progressive Matrices - a methodology commonly used for IQ assessment involving completion of pattern sequences. The test is a well validated measure of general ability with minimal dependence on cultural factors. “Both of these tests require fast brain power and the Raven’s task was conducted under time pressure,” says Dr. Rae. “The results were clear with both our experimental groups and in both test scenarios: creatine supplementation gave a significant measurable boost to brain power. For example in the digit span test subjects ability to remember long numbers, like telephone numbers, improved from a number length of about 7 to an average of 8.5 digits.”

The study shows that increased creatine intake results in improved brain function, similar to effects shown previously in muscle and heart. The results agree with previous observations showing that brain creatine levels correlate with improved recognition memory and reduce mental fatigue. “These findings underline a dynamic and significant role of brain energy capacity in influencing brain performance,” says Dr. Rae. “Increasing the energy available for computation increases the power of the brain and this is reflected directly in improved general ability.”

More Creatine Monohydrate Information

1. What is it and where does it come from?

Simply put, creatine monohydrate is the most popular and effective bodybuilding supplement on the market. Everyone consistently using creatine is making HUGE, AMAZING gains!

So, what is creatine? Our bodies naturally make the compound, which is used to supply energy to our muscles. It is produced in the liver, pancreas, and kidneys, and is transported to the body's muscles through the bloodstream. Once it reaches the muscles, it is converted into phosphocreatine (creatine phosphate). This high-powered metabolite is used to regenerate the muscles' ultimate energy source, ATP (adenosine triphosphate).

Unlike steroids or drugs, creatine is 100% natural and occurs naturally in many foods; therefore, it can never be banned from any sports or international competitions (unless they banned eating meat). Many foods especially herring, salmon, tuna, and beef contain some creatine. However, the very best source of creatine by far is creatine monohydrate because it contains more creatine per weight of material than any other source.

2. What does it do and what scientific studies give evidence to support this?

Creatine is bodybuilding's ultimate supplement, and for good reason. For one thing, creatine can significantly increase lean muscle mass in just two weeks. It is also responsible for improving performance in high-intensity exercise, increasing energy levels, and speeding up recovery rates. It’s no wonder athletes who use it have such of an edge over those who do not. Soon nearly every athlete who competes will use it (if they don't already). Creatine's ability to enhance energy reserves in muscles comes from its muscle protein synthesizing action, while minimizing protein breakdown. This occurs because creatine has the awesome effect of super-hydrating muscle cells with water. It enhances muscles' growth too-making muscle fibers bigger and stronger.

Quite a few studies have been done on creatine to figure out why and how it works so well. There have been over twenty double blind (meaning neither the researchers nor the subjects knew who was getting what), placebo-controlled studies conducted on creatine in the past five years. They proved that creatine increased energy levels, resulting in increased strength, endurance levels, and recovery rates. Another unexpected benefit attributed to creatine was discovered as well: creatine accelerates fat loss, while building lean body mass!

3. Who needs it and what are some symptoms of deficiency?

First, anyone who is ready to have more energy, build more muscle faster, and have more endurance should try supplementing with creatine monohydrate. Next, anyone who would like to be more toned by increasing lean muscle mass, recuperating faster, and losing that extra little fat roll should supplement with creatine monohydrate. Last, anyone who is involved in intense physical activity, experiencing physical stress and fatigue, and likes incredible results should supplement with creatine monohydrate.

4. How much should be taken? Are there any side effects?

Excellent results have been observed in taking creatine monohydrate in two different ways. The first way is called loading. This method works very well for anyone who has never taken creatine before. Just as the name implies, it involves loading up or saturating your muscles with creatine. During the first four days to a week, take 20 to 30 grams per day. Mix it with non-acidic juice. Grape juice works well. Gatorade may also be a good choice as there is some evidence that the electrolytes may also help with uptake. After this loading period, take a regular intake of between five to fifteen grams per day to keep your muscles saturated (no need to over do it). The other method is a more gradual approach to supplementing with creatine monohydrate. Over the course of an extended period, one basically skips the loading phase and just supplements with five to fifteen grams per day, everyday. The best results have been noticed when creatine is combined with a high carbohydrate base, such as dextrose (glucose) and taken about one-half hour before training.

The best part about creatine-no adverse effects have been reported in any studies. NONE! Creatine is totally safe and effective. Creatine has never been shown harmfully toxic. Nevertheless, just like with anything, it is not recommended to over-supplement once your muscles are saturated with creatine-there is no reason to. This means, stick to the recommended dosages, and be prepared to experience the very best muscle, strength, energy, and endurance gains possible!

Creatine Questions and Answers

Q: I heard that creatine and caffeine can be consumed at the same time. But an article I read claims caffeine inhibits the absorption of creatine into muscle tissue. Which is true?

A: There was a controversial research study published in 1996 in the journal of Applied Physiology about creatine and caffeine; however, if you study that article closely, you'll find that caffeine had no effect on creatine uptake into muscle. A more recent study by Vanakoski, et al. in 1998 investigated the pharmacokinetics of caffeine and creatine, both alone and in combination. They reported when creatine was used alone or even in combination with caffeine that, "creatine was rapidly and efficiently absorbed, as reflected by plasma concentrations." Because researchers concluded that creatine was efficiently absorbed even when combined with caffeine, it does not appear from the results of this study that caffeine exerts a negative effect on the uptake of creatine into muscle tissue.

Q: I have heard conflicting information about cycling creatine. Should I or shouldn't I?

A: Some studies support creatine cycling and others do not. There are a couple of different "cycling" strategies you can try: 1. Stay on creatine all the time, but reload once every six weeks; 2. Load for a week, stay in your maintenance phase for six weeks, then stop taking creatine completely for a couple of weeks. Repeat.

Q: I mix creatine with my workout drink in the morning, but sometimes I don't actually finish it until several hours later. Is creatine stable in solution this long?

A: Creatine is not totally stable in solution, so it's definitely not a good idea to keep it mixed with liquid for days, but there shouldn't be a problem mixing it six to eight hours before it's consumed. Any longer than that and you may be pushing it.

Q: Creatine supplementation seems to increase muscle strength. Would it make a person's heart stronger since it is a muscle too?

A: Research has shown that the cardiac tissue of laboratory animals does, indeed, take up creatine; not to the same magnitude as skeletal muscle but to some degree. There are reports of patients with chronic heart failure having low levels of myocardial creatine, and in that situation, administration of creatine is beneficial.

Q: There's been a lot of press coverage in the past about creatine and muscle cramping. Are studies underway to investigate this?

A: Many scientific studies have been published and presented about creatine over the past years, and we have never seen any scientific evidence that creatine increases an athlete's chances of experiencing muscle cramps or "pulls." In fact, results from one recent study conducted at the University of Memphis (entitled "Effects of Creatine Supplementation During Training on the Incidence of Muscle Cramping, Injuries, and GI Distress") revealed no reports of muscle cramping in subjects taking creatine-containing supplements during various exercise-training conditions. Among the test subjects were elite junior swimmers, college football players, and trained and untrained endurance athletes.

Q: Is the loading phase with Creatine necessary to experience any benefits?

A: Necessary is a rather strong word. The loading phase is not required when using Creatine, but results of our university studies indicate that the loading phase helps you reach that magic muscle-creatine saturation point quicker than if you just started out with the maintenance dose. You can reach the same creatine saturation point by taking one serving of Creatine for 30 days as you would from loading for 5 days, but most people aren't interested in waiting a month for results they could see in a week or less.

Q: Are there any unfavorable effects with using Creatine?

A: Creatine occurs naturally in many foods, with an especially high concentration in red meats and fish. While using Creatine, you may notice increased urination, but this is simply due to the extra volume of liquid you'll be drinking when mixing your Creatine. If you do not wait three to four hours between doses, you may experience some stomach discomfort. This is easily resolved by spacing your Creatine dosages throughout the day or cutting dosages in half for one to two days.

Q: What is the advantage of taking creatine in a powder versus a capsule or tablet form?

A: the bloodstream can absorb Powder more efficiently than a pill, which has a coating that must be digested first. Also, creatine is taken in gram amounts-which means, you'd need to take 20 1-gram capsules or 40 tablets per day to load. Needless to say, powder is much more efficient.

Q: If I'm trying to lose fat, should I worry about the calories in Creatine?

A: No. Creatine has no caloric value. Some of the new fancy designer products have different types of sugars added i.e. Celltech, but Jason’s Plain Old Creatine was named that for a very good reason. It is just pure pharmaceutical grade creatine and contains nothing else including calories!

New Study About Creatine's Safety!

Athletes who use the energy-building supplement creatine can train without raising their risk of injury, researchers say.

``Now we are seeing trends; everybody is finding similar results,'' said researcher Mike Greenwood of Arkansas State University.

Some preliminary reports even indicate the risk of injury is lower among athletes who take the supplement. Although these are not definitive studies, the pattern of the findings argues against some criticisms of the training aid.

Creatine, which is present naturally in the body, works by increasing the muscle's ability to refuel quickly. Supplementation is aimed at making sure enough creatine is always available for the job. Greenwood and his colleagues compared Arkansas State baseball players who were using creatine with those who were not. Users reported fewer cases of muscle pulls or strain, missed practices due to injury, and cramping.

Users knew they were getting creatine, leaving open the possibility that the knowledge may have affected their training plans or expectations of results. However, their workouts were carefully monitored and did not deviate from what researchers or the team trainer expected, Greenwood said.

Researchers also had players report on signs of overtraining. The scientists found no perceived differences in fatigue suffered by creatine users and nonusers. However, there were indications that users were less likely to feel they were overtrained and were less likely to report arm and shoulder fatigue, while nonusers were more likely to report feeling they were falling behind in their training.

The findings were reported at several scientific meetings. They amount to early results from an ongoing project to determine the relative risks faced by users and nonusers, said exercise physiologist Conrad Earnest of the Cooper Institute, a Dallas-based research organization that focuses on exercise. Earnest's role is to combine results from Greenwood and other collaborators into a database large enough to let statisticians draw more meaningful conclusions. Data so far show that creatine users don't have more cramping or muscle tears than do nonusers, Earnest said.

Greenwood and his colleagues noted earlier reports that athletes using creatine had cramping and other problems they attributed to creatine. And Earnest said pro football trainers have blamed creatine for such problems. But those claims have not stood up to repeated scientific examinations, the researchers said.

The current findings do not surprise researcher Jeff Volek of the University of Connecticut. Creatine can help athletes get in some extra lifts in training, or some extra force in a game, but the effect is not so powerful that athletes "can exceed breaking points for muscle tendons and fibers," he said. "All creatine is doing is letting you do a few extra reps in weight training, or cut a tenth of a second off your time," Volek said. "You are looking at a 5 to 10 percent performance improvement."

Athletes on creatine might overtrain and might hurt themselves, but this would be the result of the athletes expecting to do more than they can,Volek said. "If you want to go from training four days to training seven days, that could lead to overtraining, but that's not creatine's fault," he said.

Research undertaken by scientists at the University of Sydney and Macquarie University in Australia has shown that taking creatine, a compound found in muscle tissue, as a dietary supplement can give a significant boost to both working memory and general intelligence. The work monitored the effect of creatine supplementation on 45 young adult vegetarian subjects in a double-blind, placebo-controlled experiment.

“The level of creatine supplementation chosen was 5g per day as this is a level that has previously been shown to increase brain creatine levels. This level is comparable to that taken to boost sports fitness,” explains Dr. Caroline Rae who led the research. ”Vegetarians or vegans were chosen for the study as carnivores and omnivores obtain a variable level of creatine depending on the amount and type of meat they eat - although to reach the level of supplementation in this experiment would involve eating around 2 kg of meat a day!”